Integrated Dynamics is pioneering high-temperature fermentation (HTF), a biological platform leveraging hyperthermophiles (high-temperature microbes) for sustainable hydrocarbon production.
A note to the reader:
As we celebrate two years in operation today, we would like to thank you all for being a part of this journey. It takes a village to make a difference, so before we get into talking about ourselves it’s only right that we express our gratitude. You have funded, guided, and otherwise supported us in innumerable ways and for that we will always be indebted.
To a happy and healthy 2025,
Henry, Niranjan, Jake, and Corey
The synthetic hyperthermophile.
Just a few months after launching our synthetic biology initiative and welcoming Corey to the team, we’ve achieved a major milestone: Integrated Dynamics has performed the highest-ever temperature heterologous expression of an enzyme with confirmed secretion and function. The enzyme in question will massively expand the types of feedstocks compatible with our platform, and is currently being optimized for expression, affinity, and activity.
What matters most here is not the feat, but what it means for our biology workflows going forward: the methods involved in this milestone are far from standard lab practice, and what we now have is a set of protocols that can take us from idea to in vivo hyperthermophile expression in mere weeks. The possibilities for platform development extend from new feedstocks and high-performance microbes, all the way to a wider spectrum of end metabolites across fuels, chemicals, and materials.
What else is new?
We were awarded a $50K VO-1 Voucher by ENERGYWERX to partner with EcoEngineers in developing a FOAK LCA for our high-temperature fermentation pathways.
We’re excited to announce the addition of Carl Wolf as an advisor. Carl is the Chief Commercial and Operating Officer at Newlab, and previously was Chief Operating Officer of LanzaTech.
We will be hosting Pat Ferguson for a SkillBridge fellowship as he finishes up his service with the 101st Airborne Division. Pat’s background in Systems Engineering will help us develop the logistics involved with large-scale biorefining deployments.
We’re continuing to build out our commercial partnerships as we approach piloting, receiving new Letters of Support from EPCs, ethanol-based biorefiners, renewable energy project developers, and the US Army Ground Vehicle Systems Center.
We’ve been accepted to the NVIDIA Inception Program, which gives us greater access to ML and compute power for our work in metabolic and enzymatic modeling.
If you’d like to learn more, reach out at hmarkarian@int-dyn.com or over LinkedIn.